PT. Ferron Par Pharmaceuticals, Indonesia

PT. Dexa Medica

Nitroglycerin

10 mg / 10 ml

24 months

Solution for injection

Box of 10 ampoules x 10 ml

VN-21940-19

March 20, 2019

March 20, 2024

Cardiovascular drug

- Surgical procedures:
+ Rapid control of hypertension in cardiac surgery
+ Induction of controlled hypotension during surgical procedures
+ Management/control of myocardial ischemia during and following surgery
- Congestive heart failure (as adjunctive therapy in combination with other agents).
- Unstable angina pectoris refractory to treatment with beta-blockers and sublingual nitrates.

The dosage of nitroglycerin should be adjusted according to individual patient requirements and the hemodynamic response monitored. The recommended dose ranges from 10 to 200 mcg/min, although doses up to 400 mcg/min may be required during certain surgical procedures.
Surgery:
A starting dose of 25 mcg/min is recommended for the control of hypertension or induction of controlled hypotension during surgical procedures. This may be titrated up by increments of 25 mcg/min at 5-minute intervals until target blood pressure is stabilized. A dose between 10 and 200 mcg/min is usually sufficient during surgery, although doses up to 400 mcg/min have been required in some cases.
Treatment of perioperative myocardial ischemia is initiated at a dose of 15 to 20 mcg/min, with subsequent increases of 10 to 15 mcg/min until the desired effect is achieved.
Unresponsive Congestive Heart Failure:
The recommended starting dose is 20 to 25 mcg/min. This dose may be reduced to 10 mcg/min or titrated upwards by 20 to 25 mcg/min every 15 to 30 minutes until the desired clinical response is obtained.
Unstable Angina Pectoris:
The recommended initial dose is 10 mcg/min, with titrations of 10 mcg/min increments approximately every 30 minutes according to the patient’s clinical response.